NUR 590 Topic 6 DQ 2 Discuss the difference between statistically significant evidence and clinically significant evidence – Online Nursing Essays

NUR 590 Topic 6 DQ 2 Discuss the difference between statistically significant evidence and clinically significant evidence

NUR 590 Topic 6 DQ 2 Discuss the difference between statistically significant evidence and clinically significant evidence

Click here to ORDER an A++ paper from our Verified MASTERS and DOCTORATE WRITERS: NUR 590 Topic 6 DQ 2 Discuss the difference between statistically significant evidence and clinically significant evidence

NUR 590 Topic 6 DQ 2

Discuss the difference between statistically significant evidence and clinically significant evidence. How would each of these findings be used to advance an evidenced-based practice project?

Significant evidence is defined statistically as the discovery that an occurrence differs from the theoretical only by chance. The null hypothesis (no association or change), the p-value (probability), and the degree of significance are all addressed in statistical significance (data collected previous to study). Statistics assist academics, businesses, and other entities in understanding the scope of an experiment’s, survey’s, or poll’s conclusions (Ranganathan et al., 2017). Ranganathan and his associates (2017) The goal of statistical significance is to ensure the existence of an effect. The findings of a specific study can help decision-makers. However, truth, efficacy, or relevance should not be the primary determinant.

Clinically meaningful evidence is defined as the achievement of actual and measurable results through intervention. Clinical significance is determined by the impacted size (multiple variable correlation), the number needed to treat (the affected sample size), and the Jacobson-Truax test (calculates reliability change index). Significant clinical findings are far more easily replicated in practice than significant statistical findings and can thus be used when even a small margin of error is too large (MHA, 2021). The clinical significance of an influence is concerned with determining its magnitude and scope. This is a must-have resource for policymakers with an interest in pharmaceutical, psychological, and medical fields.

Statistical significance must always be considered before clinical significance in evidence-based research practice. The research project’s evidence-based clinical importance will be used to promote good project findings that coincide with statistically significant results.


MHA. (2021). Clinical Significance vs. Statistical Significance – Side-by-Side Comparison. Mhaonline.

Ranganathan, P., Pramesh, C., & Buyse, M. (2017). Common pitfalls in statistical analysis: Clinical versus statistical significance. Perspectives in Clinical Research6(3), 169.

The distinction between statistical and clinical significance is that the former reflects the reliability of the study results, whereas the latter reflects how a study affects one’s clinical practice (Ranganathan et al., 2015). Statistical significance can be quantified and measured. When compared to the acceptable level of uncertainty, it can calculate the probability of a null hypothesis being correct (Tenny & Abdelgawad, 2021). This basically determines whether the results obtained are true and not just a result of chance. Clinical significance, on the other hand, refers to the magnitude of the actual treatment effect (Ranganathan et al., 2015).

These findings can be used to advance an evidence based-practice project . It is important to note that statistical significance is not the same as clinical significance. Statistical significance can assist a researcher to whether reject or accept the null hypothesis or use the alternative hypothesis (Tenny & Abdelgawad, 2021). Clinical significance can have implications to the current trends in practice because it may or may not create a positive impact in patient care delivery.


Ranganathan, P., Pramesh, C. S., & Buyse, M. (2015). Common pitfalls in statistical analysis: Clinical versus statistical significance. Perspectives in Clinical Research6(3), 169–170.

Tenny, S. & Abdelgawad, I. (2021). Statistical significance. StatPearls Publishing; Available from:

Statistically significant evidence is when an event occurs and the result is thought to be not random in occurrence (Zbrog, n.d.). It is utilized when the researcher is attempting to see if something is not happening by chance, and Zbrog (n.d.) states that it would be well utilized in the initial stages of pharmaceutical trials. Clinically significant evidence is when the results are after a treatment has have results that are quantifiable (Zbrog, n.d.). Zbrog (n.d.) states that this type of significance is mostly utilized in the medical field and among pharmaceutical researchers, really wherever there is an intervention that the researcher needs to be able to measure and quantify. In our EBP projects there is room for both types of evidence. Obviously for most of us we are producing new interventions/ways to do things and therefore are looking at clinically significant evidence, because if our new way of thinking and doing things makes a difference that is significant to practitioners everywhere. With statistically significant evidence, we might not all find this within our own projects but it does have its place in EBP. In my EBP project in the phase where the facility will be utilizing a survey for all patients, it could be found statistically that most of the people agreeing to take the STD test are men who sleep with men. Furthermore, this could reflect that it is MSM who are more likely to have an STD, as most of the other research I have done have found this. It would be interesting to see if this infact happens, or if the other researchers were in areas with higher rates of homosexual STD spread, on purpose or otherwise. There are many reasons one might want this statistical data, it is not significant to my study and would only be statistically significant, whereas the outcome of my intervention is most important to me, and is clinically significant evidence.

Zbrog, M. (n.d.). Clinical Significance vs. Statistical Significance – Side-by-Side Comparison. Mhaonline. Retrieved September 21, 2021, from

The successful implementation of an evidence-based practice (EBP) proposal depends on the ability of an investigator to synthesize and interpret data collected from research. Therefore, the findings of a study must be differentiated based on their relevance in improving the reliability of research and on their reliance on being applicable within the clinical context. Statistically, significant evidence is a finding that suggests a positive relationship between variables that happened by chance (Schober, Bossers, & Schwarte, 2018). This aspect is evaluated a probability value (p-value) which suggests that a finding is statistically significant if its p-value is above 0.005. The discovery of a finding that is statistically significant allows an investigator to evaluate the parameters of using the study results to justify or confirm the parameters of the EBP proposal. The likelihood that a study finding is true provides the confidence of using the information on evaluating an EBP.

 Read Also: Evidence-Based Practice Project Proposal Implementation Plan NUR 590

Click here to ORDER an A++ paper from our Verified MASTERS and DOCTORATE WRITERS: NUR 590 Topic 6 DQ 2 Discuss the difference between statistically significant evidence and clinically significant evidence

On the other hand, clinical significance refers to an evaluation of evidence-based subjective interpretation in terms of its application within a clinical setting. It directly relates to the relevance of information from a study and its impact on patient care; therefore, it influences the healthcare provider’s decision-making process within a practice context (Schober, Bossers, & Schwarte, 2018). Clinically significant evidence can alter and change the existing practice principles and procedures due to its ability to integrate with the practical concerns of care. Therefore, this finding can be used as a supportive element to promoting positive outcomes of an EBP project that is already established to be statistically significant.


Schober, P., Bossers, S. M., & Schwarte, L. A. (2018). Statistical significance versus clinical importance of observed effect sizes: what do P values and confidence intervals really represent?. Anesthesia and analgesia126(3), 1068

According to Ranganthan et. al., clinical research and study results provide information concerning reliability and validity of study results, whereas clinical significance is regarding whether or not the results and information is truly useful and significant in relation to its impact on clinical practice and patient outcomes (2015). Significance does not always mean importance, and importance does not always equate to significance.


Now, it is still important to understand the significance of both clinical research and clinical significance, and their parts in evidence-based practice projects. Looking at statistical significance, or results reliability and validity, is essential to reviewing the literature and understanding whether or not the results have occurred via happenstance, or if there is a true correlation between variables based on sample size(Ranganathan et. al., 2015). This allows researchers and clinicians alike to know whether or not they should move forward in their pursuit of evidence-based practice changes, based upon reliable and valid evidence that means something. Moving forward in the process, clinical significance is the next step that examines the extent to which the correlated variables and practice outcomes are meaningful to the patient at the bedside, so to speak. Both are significant in the evidence-based project process, and must be continually reexamined to ensure effective and meaningful outcomes are prioritized for the patient.


Ranganathan, P., Pramesh, C.S. and Buyse, M. (2015). Common pitfalls in statistical analysis: Clinical versus statistical significance. Perspectives in Clinical Research, 6(3), 169-170.

Clinically significant evidence and statistically significant evidence are related, but do not mean the same thing. Statistical significance utilizes the probability value (p-value), and it tells a researcher the probability or chance that the results from the study are a random occurrence versus an actual difference between the variables (Heavey, 2015). Statistical significance also uses the alpha value and when the analysis of the results of the study are done and the p-value is less than the alpha value, it means that the data shows the results was real and did not occur by chance which makes the results statistically significant. When it comes to clinical significance, the researchers determine if the statistical significance is substantial enough to be clinically important and should be used to help direct the course of patient care (Heavey, 2015). Sometimes the results may be statistically significant, although may not clinically significant meaning that the results does not show that it is helpful and should not be used to help guide clinical practice. With this though, statistical significance has to be established before clinical significance can be determined (Heavey, 2015).

Each of these findings can be used to advance an evidence-based practice (EBP) project. Statistical significance helps to determine if something occurred by chance or not. If it did not occur by chance, that means it is statistically significant and can help determine the strength of the evidence against the null hypothesis (Armijo-Olivo, 2018). Clinical significance can be used to advance EBP by determining whether the results of the study are meaningful to clinical practice in a way that the intervention that was tested, its effects are big enough to make the costs, any inconveniences, and harms worthwhile to improve clinical practice and patient care (Armijo-Olivo, 2018).


Armijo-Olivo, S. (2018). The importance of determining the clinical significance of research results in physical therapy clinical research. Brazilian Journal of Physical Therapy, 22(3), 175-176.

Heavey, E. (2015). Differentiating between statistical significance and clinical significance. American Nurse today, 10(5), 26-28.


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